This presentation provides a comprehensive overview of high-performance life science laboratories, focusing on four key areas: design and infrastructure, safety, collaboration, and sustainability. It begins by exploring modern laboratory design principles, emphasizing optimal layouts, safety, and compliance, highlighted by a case study of Wilmar International. The next section delves into safety consideration in lab facility with insight from A-Star Skin Research Institute of Singapore project in Singapore. The importance of collaborative spaces and interdisciplinary research is then discussed, showcasing successful projects and design features that promote teamwork at A-Star Infectious Disease Laboratory, Singapore. Finally, the presentation addresses sustainability, detailing green practices, energy efficiency, and resource management, illustrated by a sustainable lab design case study at NUS Tahir Foundation building. The session concludes with a summary of key points and an interactive Q&A, ensuring a thorough understanding of the critical role these facilities play in advancing life sciences.